Equine arterivirus serine peptidase

Equine arterivirus serine peptidase (EC 3.4.21.114) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of (Glu/Gln)-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab
Equine arterivirus serine peptidase
Identifiers
EC no.3.4.21.114
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab [polyprotein]s.

References
  1. Snijder EJ, Wassenaar AL, van Dinten LC, Spaan WJ, Gorbalenya AE (March 1996). "The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases". The Journal of Biological Chemistry. 271 (9): 4864–71. doi:10.1074/jbc.271.9.4864. PMID 8617757.
  2. van Dinten LC, Rensen S, Gorbalenya AE, Snijder EJ (March 1999). "Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication". Journal of Virology. 73 (3): 2027–37. doi:10.1128/JVI.73.3.2027-2037.1999. PMC 104445. PMID 9971783.
  3. Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN (October 2002). "Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole". The Journal of Biological Chemistry. 277 (42): 39960–6. doi:10.1074/jbc.m206978200. PMID 12163505.


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