Erez Lieberman Aiden

Lieberman Aiden was part of a team of scientists from the University of Massachusetts Medical School and MIT that first suggested human DNA folds into a fractal globule rather than an equilibrium globule.[4] This finding explains how each cell's genome is able to be heavily compacted without forming a knot. Lieberman Aiden and coworkers invented a variant of chromosome conformation capture called "Hi-C" which produces a genome-wide measure of contact probabilities that point to a 3-dimensional genome structure. This technique combines existing chromosome capture methodology with next-generation sequencing, enabling an all-versus-all measure of chromatin contacts.[9]

In 2009 this work was published in the journal Science and was featured as a cover illustration.[10] Following the publication, Lieberman Aiden was quoted as saying:[11]

We’ve long known that on a small scale, DNA is a double helix … But if the double helix didn’t fold further, the genome in each cell would be two meters long. Scientists have not really understood how the double helix folds to fit into the nucleus of a human cell, which is only about a hundredth of a millimeter in diameter. This new approach enabled us to probe exactly that question.[11]

In 2014, he served as a senior author on an article in Cell which described a refined method of Hi-C which his team used to describe the fundamental organization of DNA.[12]

Erez Lieberman Aiden lecturing on culturomics at Harvard University in 2011

Lieberman Aiden was involved in the analysis of a corpus of around 5 million digitised books, applying data mining techniques to advance the new field of culturomics.[13][14] Leiberman Aiden was involved in a project to digitise Anglo-Saxon texts in 2004, analysis of which provided supporting evidence for verb regularisation, a process whereby irregular verbs become increasingly regular over time.[15]

After the announcement of Google Books, Lieberman Aiden approached Google's Director of Research Peter Norvig and was permitted to statistically analyse their data.[16] His work contributed to the Google Ngram Viewer, released in December 2010, which makes use of culturomics ideas to produce normalized historical trends for any sequence of letters.[13] This project published a number of findings in the journal Science, including the changing dynamic of fame and instances of literary censorship during the Second World War.[17]

In 2008 Lieberman Aiden was awarded the Lemelson-MIT Student Prize for his work on the iShoe, meant to assist elderly people with balance problems and prevent falls that could cause injury.[18][19] The following year, the iShoe was listed as one of "20 New Biotech Breakthroughs that Will Change Medicine" by Popular Mechanics.[20] A year later Lieberman Aiden was named as one of 35 top innovators under 35 (TR35) by MIT's Technology Review magazine.[21]

In 2010, the American Physical Society presented Lieberman Aiden with the Award for Outstanding Doctoral Thesis Research in Biological Physics for his thesis titled "Evolution and the emergence of structure".[22] His doctoral dissertation was also awarded the Hertz Thesis Prize.[23] Lieberman Aiden is also the recipient of an NIH Director's New Innovator Award and was named, along with 95 other American researchers, as a recipient of the Presidential Early Career Award for Scientists and Engineers in 2011.[24]