Eric Meggers

Eric Meggers (born 10 May 1968 in Bonn, Germany) is a German chemist and professor of organic chemistry and chemical biology at the University of Marburg, Germany. His research currently focuses on the design of chiral catalysts for stereoselective synthesis.

Biography

Born in Bonn, Germany, Meggers studied chemistry at the University of Bonn and subsequently received his Ph.D. in 1999 under Bernd Giese at the University of Basel, Switzerland. After postdoctoral research at the Scripps Research Institute in La Jolla, USA, Meggers started his independent career in 2002 as assistant professor at the University of Pennsylvania, USA. Since 2007, Meggers is full professor of organic chemistry and chemical biology at the University of Marburg, Germany.

Research

Meggers specializes on exploiting metal-centered stereochemistry for applications in medicine, chemical biology, and asymmetric catalysis.[1] The research program started with the design of metal-based protein kinase inhibitors,[2] the subsequent design of chiral organocatalysts based on inert metal complexes (metal-templated organocatalysis),[3] and finally arrived at the current focal point of developing chiral transition metal catalysts featuring exclusively metal-centered chirality (chiral-at-metal catalysts).[4][5]

Other unrelated previous research:

  • Glycol nucleic acid (GNA): Establishing the Watson-Crick base pairing ability of the minimal nucleic acid GNA containing an acyclic three-carbon propylene glycol phosphodiester backbone.[6]
  • Bioorthogonal catalysis: Development of organometallic complexes for catalysis in living biological systems.[7][8]

References
  1. Meggers, Eric (2017-05-15). "Exploiting Octahedral Stereocenters: From Enzyme Inhibition to Asymmetric Photoredox Catalysis". Angewandte Chemie International Edition. 56 (21): 5668–5675. doi:10.1002/anie.201612516. PMID 28328151.
  2. Feng, Li; Geisselbrecht, Yann; Blanck, Sebastian; Wilbuer, Alexander; Atilla-Gokcumen, G. Ekin; Filippakopoulos, Panagis; Kräling, Katja; Celik, Mehmet Ali; Harms, Klaus; Maksimoska, Jasna; Marmorstein, Ronen (2011-04-20). "Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors". Journal of the American Chemical Society. 133 (15): 5976–5986. doi:10.1021/ja1112996. ISSN 0002-7863. PMC 3076536. PMID 21446733.
  3. Xu, Weici; Arieno, Marcus; Löw, Henrik; Huang, Kaifang; Xie, Xiulan; Cruchter, Thomas; Ma, Qiao; Xi, Jianwei; Huang, Biao; Wiest, Olaf; Gong, Lei (2016-07-20). "Metal-Templated Design: Enantioselective Hydrogen-Bond-Driven Catalysis Requiring Only Parts-per-Million Catalyst Loading". Journal of the American Chemical Society. 138 (28): 8774–8780. doi:10.1021/jacs.6b02769. ISSN 0002-7863. PMC 8103658. PMID 27336458.
  4. Zhang, Lilu; Meggers, Eric (2017-02-21). "Steering Asymmetric Lewis Acid Catalysis Exclusively with Octahedral Metal-Centered Chirality". Accounts of Chemical Research. 50 (2): 320–330. doi:10.1021/acs.accounts.6b00586. ISSN 0001-4842. PMID 28128920.
  5. Huang, Xiaoqiang; Meggers, Eric (2019-03-19). "Asymmetric Photocatalysis with Bis-cyclometalated Rhodium Complexes". Accounts of Chemical Research. 52 (3): 833–847. doi:10.1021/acs.accounts.9b00028. ISSN 0001-4842. PMID 30840435. S2CID 73503362.
  6. Meggers, Eric; Zhang, Lilu (2010-08-17). "Synthesis and Properties of the Simplified Nucleic Acid Glycol Nucleic Acid". Accounts of Chemical Research. 43 (8): 1092–1102. doi:10.1021/ar900292q. ISSN 0001-4842. PMID 20405911.
  7. Streu, Craig; Meggers, Eric (2006-08-25). "Ruthenium-Induced Allylcarbamate Cleavage in Living Cells". Angewandte Chemie International Edition. 45 (34): 5645–5648. doi:10.1002/anie.200601752. ISSN 1433-7851. PMID 16856188.
  8. Völker, Timo; Meggers, Eric (April 2015). "Transition-metal-mediated uncaging in living human cells — an emerging alternative to photolabile protecting groups". Current Opinion in Chemical Biology. 25: 48–54. doi:10.1016/j.cbpa.2014.12.021. PMID 25561021.
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