Exonuclease 5
Exonuclease 5 is a protein that in humans is encoded by the EXO5 gene. [5]
| EXO5 | |||||||||||||||||||||||||||||||
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| Aliases | EXO5, C1orf176, DEM1, Exo V, hExo5, exonuclease 5 | ||||||||||||||||||||||||||||||
| External IDs | MGI: 1920422 HomoloGene: 41497 GeneCards: EXO5 | ||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016].
References
- GRCh38: Ensembl release 89: ENSG00000164002 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000028629 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Exonuclease 5". Retrieved 2018-04-27.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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