Exosome component 1

EXOSC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC1, CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13, Exosome component 1, PCH1F
External IDs	OMIM: 606493 MGI: 1913833 HomoloGene: 9359 GeneCards: EXOSC1
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	97,446,017 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	41,921,862 bp[2]
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; body of pancreas; ; monocyte; ; anterior pituitary; ; body of stomach; ; prefrontal cortex; ; spleen; ; lymph node; ; canal of the cervix; ; smooth muscle tissue;
	Top expressed in
	morula; ; otic placode; ; secondary oocyte; ; interventricular septum; ; Paneth cell; ; internal carotid artery; ; abdominal wall; ; maxillary prominence; ; external carotid artery; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	exoribonuclease activity; protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; nuclear exosome (RNase complex); nucleolus; exosome (RNase complex); nucleoplasm; nucleus;
Biological process	regulation of mRNA stability; exonucleolytic catabolism of deadenylated mRNA; rRNA processing; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA processing;
	Sources:Amigo / QuickGO
Orthologs
	51013
	66583
	ENSG00000171311
	ENSMUSG00000034321
	Q9Y3B2
	Q9DAA6
NM_016046; NM_001318362; NM_001318363; NM_001318364; NM_001318365;
	NM_001318366
	NM_001164561; NM_025644; NM_001320231; NM_001320232; NM_001320233
NP_001305291; NP_001305292; NP_001305293; NP_001305294; NP_001305295;
	NP_057130
	NP_001158033; NP_001307160; NP_001307161; NP_001307162; NP_079920
	Wikidata
View/Edit Human	View/Edit Mouse

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.[5][6][7]

This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.[7]

Interactions

Exosome component 1 has been shown to interact with:

References

GRCh38: Ensembl release 89: ENSG00000171311 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034321 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J Mol Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
"Entrez Gene: EXOSC1 exosome component 1".
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
van Hoof A, Staples RR, Baker RE, Parker R (2000). "Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA". Mol. Cell. Biol. 20 (21): 8230–43. doi:10.1128/MCB.20.21.8230-8243.2000. PMC 86432. PMID 11027292.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171311 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034321 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11812149-5] Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J Mol Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.

[pmid11719186-6] Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.

[entrez-7] "Entrez Gene: EXOSC1 exosome component 1".

[pmid12419256-8] Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.

Exosome component 1

Interactions

References

Further reading