F-box protein 40

FBXO40
Identifiers
Aliases	FBXO40, FBX40, F-box protein 40
External IDs	OMIM: 609107 MGI: 2443753 HomoloGene: 9459 GeneCards: FBXO40
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	121,630,295 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	36,810,829 bp[2]
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; triceps brachii muscle; ; body of tongue; ; right ventricle; ; atrium; ; vena cava; ; gastrocnemius muscle; ; thoracic diaphragm; ; deltoid muscle; ; superior surface of tongue;
	Top expressed in
	skeletal muscle tissue; ; quadriceps femoris muscle; ; secondary oocyte; ; heart; ; zone of skin; ; proximal tubule; ; kidney; ; esophagus; ; lip; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; metal ion binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; molecular function;
Cellular component	cytoplasm; cytosol;
Biological process	muscle cell differentiation; protein polyubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	51725
	207215
	ENSG00000163833
	ENSMUSG00000047746
	Q9UH90
	P62932
	NM_016298
	NM_001037321; NM_001358217
	NP_057382
	NP_001032398; NP_001345146
	Wikidata
View/Edit Human	View/Edit Mouse

F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling (Shi et al, 2011).[5][6]

Function

Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.[7]

Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 causes ubiquitination and degradation of IRS1, blocking further signaling downstream of the IGF1 receptor.[5]

References

GRCh38: Ensembl release 89: ENSG00000163833 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047746 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi:10.1016/j.devcel.2011.09.011. PMID 22033112.
"Entrez Gene: F-box protein 40". Retrieved 2017-11-24.
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163833 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047746 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid22033112-5] Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi:10.1016/j.devcel.2011.09.011. PMID 22033112.

[entrez-6] "Entrez Gene: F-box protein 40". Retrieved 2017-11-24.

[pmid15520277-7] Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.