FAAH2

Fatty acid amide hydrolase 2 or FAAH2 (EC 3.5.1.99, oleamide hydrolase 2, anandamide amidohydrolase 2) is a member of the serine hydrolase family of enzymes.[3]

FAAH2
Identifiers
AliasesFAAH2, AMDD, fatty acid amide hydrolase 2
External IDsOMIM: 300654 HomoloGene: 45263 GeneCards: FAAH2
Orthologs
SpeciesHumanMouse
Entrez

158584

n/a

Ensembl

ENSG00000165591

n/a

UniProt

Q6GMR7

n/a

RefSeq (mRNA)

NM_174912
NM_001353840
NM_001353841

n/a

RefSeq (protein)

NP_777572
NP_001340769
NP_001340770

n/a

Location (UCSC)Chr X: 57.29 – 57.49 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Fatty acid amide hydrolase 2 degrades endocannabinoids and defects in this enzyme have been associated with neurologic and psychiatric disorders.[4]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000165591 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF (December 2006). "A second fatty acid amide hydrolase with variable distribution among placental mammals". The Journal of Biological Chemistry. 281 (48): 36569–78. doi:10.1074/jbc.M606646200. PMID 17015445.
  4. Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, et al. (March 2015). "Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms". Orphanet Journal of Rare Diseases. 10: 38. doi:10.1186/s13023-015-0248-3. PMC 4423390. PMID 25885783.
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