FANCD2OS

FANCD2OS
Identifiers
Aliases	FANCD2OS, C3orf24, FANCD2 opposite strand
External IDs	MGI: 1918229 HomoloGene: 45456 GeneCards: FANCD2OS
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	10,108,255 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	113,577,676 bp[2]
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; sperm; ; muscle tissue; ; minor salivary gland; ; gastric mucosa; ; thymus; ; tendon; ; monocyte; ; right uterine tube; ; bone marrow;
	Top expressed in
	seminiferous tubule; ; spermatid; ; proximal tubule; ; morula; ; kidney; ; spermatocyte; ; blastocyst; ; salivary gland; ; yolk sac; ; left lobe of liver;
	More reference expression data
	n/a
Orthologs
	115795
	70979
	ENSG00000163705
	ENSMUSG00000033963
	Q96PS1
	Q9D4K4
	NM_173472; NM_001164839
	NM_027633
	NP_001158311; NP_775743
	NP_081909
	Wikidata
View/Edit Human	View/Edit Mouse

Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene.[5] The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.

Gene

The gene is encoded on Chromosome 3 (human) at p25.3 on the minus strand from 10081320-10108339nt. The primary transcript is 1105nt which codes for a protein of 177 amino acid in length.[6] The gene on the strand complementary to FANCD2 located 5' from CYCSP11 and 3’ from BRK1 and VHL genes.[5]

mRNA

There are six alternatively spliced transcripts with differences in the 5' and 3' ends as well changes in exon usage.[7] The most common isoform is 1105 bp.[8]

Promoter Region

The promoter region predicted by the Genomatix El Dorado algorithm spans from 10108742-10108009 bp. Promoters are associated with a wide variety of tissues including B-lymphocytes, germ cells, muscle, neurons & prostate.

Regulatory

Secondary structure of the 5’ UTR sequence conserved between humans and gibbon contain sequence recognized by to RBMX, Ras & Rab proteins. The sequence for the secondary structure of the 3’ UTR are recognized by EIF4B and RBMX.

Expression

FANCD2OS is moderately expressed in the human brain, placenta and testes.[9]

Evolutionary History

Protein sequence

The protein from the longest transcript is 177AA in length with a mass of 20188.59kD. The protein consists of a domain of unknown function from the DUF4563 superfamily.[10]

Orthologs

Orthologs of FANCD2OS exist throughout mammals, reptiles, birds and in the cartilaginous fish Australian ghostshark.[11] The protein sequence undergoes mutation at a rate similar to the blood protein fibrinogen.

Species	Common name	NCBI accession	Identity	similarity	E-value
Pongo abelii	Sumatran orangutan	XP_003776240.1	98.9	99.4	1.21E-133
Cricetulus griseus	Chinese hamster	XP_003511850.1	73.6	80.9	1.56E-95
Ovis aries	Sheep	XP_004018322.1	97.2	98.3	6.79E-131
Leptonychotes weddellii	Weddell seal	XP_006739055.1	96.6	98.3	5.13E-130
Condylura cristata	Star-nosed mole	XP_004692437.1	91.0	95.5	3.01E-123
Orcinus orca	Killer whale	XP_004286877.2	88.1	92.3	1.05E-90
Trichechus manatus latirostris	Florida manatee	XP_004368376.1	96.6	98.9	9.95E-131
Alligator mississippiensis	American alligator	XP_014457972.1	69.3	88.6	1.40E-48
Chrysemys picta bellii	Painted turtle	XP_005307285.1	58.3	75	2.18E-78
Gekko japonicus	Schlegel's Japanese gecko	XP_015261231.1	56.5	72.3	4.39E-74
Thamnophis sirtalis	Common garter snake	XP_013914711.1	55.9	69.5	2.75E-69
Xenopus laevis	African clawed frog	NP_001088778.1	55.4	71.2	1.98E-68
Xenopus tropicalis	Western clawed frog	NP_001090717.1	52	71.2	3.57E-65
Callorhinchus milii	Australian ghostshark	XP_007888744.1	39.9	56.8	5.67E-43

Paralogs

FANCD2OS has no known paralogs in Homo sapiens.

References

[6] [5] [11] [7] [10] [9]

GRCh38: Ensembl release 89: ENSG00000163705 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000033963 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene - FANCD2OS FANCD2 opposite strand Homo sapiens". Retrieved 6 February 2016.
"FANCD2 opposite strand protein". NCBI. Retrieved 2 May 2016.
"AceView C3orf24". NCBI. Retrieved 2 May 2016.
"Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant 1, mRNA". NCBI Nucleotide. NCBI. Retrieved 19 April 2016.
"NCBI - GDS592 / gnf1m17159_at / Fancd2os". NCBI. Retrieved 15 Mar 2016.
"Conserved Protein Domain Family DUF4563". NCBI. Retrieved 2 May 2016.
"Homologene: FANCD2OS". Retrieved 6 February 2016.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163705 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033963 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene - FANCD2OS FANCD2 opposite strand Homo sapiens". Retrieved 6 February 2016.

[NCBI_Protein-6] "FANCD2 opposite strand protein". NCBI. Retrieved 2 May 2016.

[AceView-7] "AceView C3orf24". NCBI. Retrieved 2 May 2016.

[NCBI_Nucleotide_NM_173472.1-8] "Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant 1, mRNA". NCBI Nucleotide. NCBI. Retrieved 19 April 2016.

[GEO_GDS592-9] "NCBI - GDS592 / gnf1m17159_at / Fancd2os". NCBI. Retrieved 15 Mar 2016.

[DUF4563-10] "Conserved Protein Domain Family DUF4563". NCBI. Retrieved 2 May 2016.

[homologene-11] "Homologene: FANCD2OS". Retrieved 6 February 2016.