FARP1

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.[5][6]

FARP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFARP1, CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDsOMIM: 602654 MGI: 2446173 HomoloGene: 38098 GeneCards: FARP1
Orthologs
SpeciesHumanMouse
Entrez

10160

223254

Ensembl

ENSG00000152767

ENSMUSG00000025555

UniProt

Q9Y4F1

F8VPU2

RefSeq (mRNA)

NM_001001715
NM_001286839
NM_005766

NM_134082

RefSeq (protein)

NP_001001715
NP_001273768
NP_005757

NP_598843

Location (UCSC)Chr 13: 98.14 – 98.46 MbChr 14: 121.27 – 121.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000152767 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025555 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun. 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278.
  6. "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)".

Further reading


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