FBLIM1

Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.[5][6][7]

FBLIM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFBLIM1, CAL, FBLP-1, FBLP1, filamin binding LIM protein 1
External IDsOMIM: 607747 MGI: 1921452 HomoloGene: 56774 GeneCards: FBLIM1
Orthologs
SpeciesHumanMouse
Entrez

54751

74202

Ensembl

ENSG00000162458

ENSMUSG00000006219

UniProt

Q8WUP2

Q71FD7

RefSeq (mRNA)

NM_001024215
NM_001024216
NM_017556
NM_001350151

NM_001163256
NM_133754
NM_001378958
NM_001378959

RefSeq (protein)

NP_001019386
NP_001019387
NP_060026
NP_001337080

Location (UCSC)Chr 1: 15.76 – 15.79 MbChr 4: 141.3 – 141.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

Interactions

FBLIM1 has been shown to interact with Filamin,[8] PLEKHC1[5] and FLNB.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000162458 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006219 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tu Y, Wu S, Shi X, Chen K, Wu C (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033. S2CID 15051526.
  6. Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS (March 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J Biol Chem. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. PMID 12496242.
  7. "Entrez Gene: FBLIM1 filamin binding LIM protein 1".
  8. Tu, Yizeng; Wu Shan; Shi Xiaohua; Chen Ka; Wu Chuanyue (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. United States. 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. ISSN 0092-8674. PMID 12679033. S2CID 15051526.
  9. Takafuta, Toshiro; Saeki Mari; Fujimoto Tetsuro-Takahiro; Fujimura Kingo; Shapiro Sandor S (April 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J. Biol. Chem. United States. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. ISSN 0021-9258. PMID 12496242.

Further reading


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