FBXO2

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.[5][6][7]

FBXO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFBXO2, FBG1, FBX2, Fbs1, NFB42, OCP1, F-box protein 2
External IDsOMIM: 607112 MGI: 2446216 HomoloGene: 8132 GeneCards: FBXO2
Orthologs
SpeciesHumanMouse
Entrez

26232

230904

Ensembl

ENSG00000116661

ENSMUSG00000041556

UniProt

Q9UK22

Q80UW2

RefSeq (mRNA)

NM_012168

NM_176848

RefSeq (protein)

NP_036300

NP_789818

Location (UCSC)Chr 1: 11.64 – 11.66 MbChr 4: 148.25 – 148.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000116661 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041556 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  7. "Entrez Gene: FBXO2 F-box protein 2".

Further reading

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