FBXO9

F-box only protein 9 is a protein that in humans is encoded by the FBXO9 gene.[5][6][7]

FBXO9
Identifiers
AliasesFBXO9, FBX9, NY-REN-57, VCIA1, dJ341E18.2, F-box protein 9
External IDsOMIM: 609091 MGI: 1918788 HomoloGene: 8217 GeneCards: FBXO9
Orthologs
SpeciesHumanMouse
Entrez

26268

71538

Ensembl

ENSG00000112146

ENSMUSG00000001366

UniProt

Q9UK97

Q8BK06

RefSeq (mRNA)

NM_012347
NM_033480
NM_033481

NM_001081490
NM_023605

RefSeq (protein)

NP_036479
NP_258441
NP_258442

NP_001074959
NP_076094

Location (UCSC)Chr 6: 53.05 – 53.1 MbChr 9: 77.99 – 78.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000112146 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001366 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  7. "Entrez Gene: FBXO9 F-box protein 9".

Further reading


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