FBXW5

FBXW5
Identifiers
Aliases	FBXW5, Fbw5, F-box and WD repeat domain containing 5
External IDs	OMIM: 609072 MGI: 1354731 HomoloGene: 8496 GeneCards: FBXW5
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	136,944,738 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	25,395,483 bp[2]
RNA expression pattern
	Top expressed in
	popliteal artery; ; gastrocnemius muscle; ; right lobe of liver; ; right coronary artery; ; left coronary artery; ; thoracic aorta; ; ascending aorta; ; left ventricle; ; body of stomach; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; entorhinal cortex; ; superior frontal gyrus; ; saccule; ; lip; ; otic placode; ; cerebellar cortex; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding; ubiquitin-protein transferase activity;
Cellular component	Cul4-RING E3 ubiquitin ligase complex; cytoplasm; SCF ubiquitin ligase complex; cytosol;
Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of centrosome duplication; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of mitotic nuclear division; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	54461
	30839
	ENSG00000159069
	ENSMUSG00000015095
	Q969U6
	Q9QXW2
	NM_018998; NM_178225; NM_178226
	NM_013908; NM_001356407; NM_001356408
	NP_061871
	NP_038936; NP_001343336; NP_001343337
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[5]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented.[5] Well established targets of FBXW5 include TSC2[6] and SEC23B.[7]

References

GRCh38: Ensembl release 89: ENSG00000159069 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000015095 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".
Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC 2279197. PMID 18381890.
Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253. PMC 6351106. PMID 30596474.

Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H (March 2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proceedings of the National Academy of Sciences of the United States of America. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159069 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015095 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".

[pmid18381890-6] Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC 2279197. PMID 18381890.

[pmid30596474-7] Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253. PMC 6351106. PMID 30596474.

FBXW5

References

Further reading