FBXW5

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[5]

FBXW5
Identifiers
AliasesFBXW5, Fbw5, F-box and WD repeat domain containing 5
External IDsOMIM: 609072 MGI: 1354731 HomoloGene: 8496 GeneCards: FBXW5
Orthologs
SpeciesHumanMouse
Entrez

54461

30839

Ensembl

ENSG00000159069

ENSMUSG00000015095

UniProt

Q969U6

Q9QXW2

RefSeq (mRNA)

NM_018998
NM_178225
NM_178226

NM_013908
NM_001356407
NM_001356408

RefSeq (protein)

NP_061871

NP_038936
NP_001343336
NP_001343337

Location (UCSC)Chr 9: 136.94 – 136.94 MbChr 2: 25.39 – 25.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented.[5] Well established targets of FBXW5 include TSC2[6] and SEC23B.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000159069 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015095 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".
  6. Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC 2279197. PMID 18381890.
  7. Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253. PMC 6351106. PMID 30596474.

Further reading

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