MS4A2

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.[5][6]

MS4A2
Identifiers
AliasesMS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDsOMIM: 147138 MGI: 95495 HomoloGene: 112 GeneCards: MS4A2
Orthologs
SpeciesHumanMouse
Entrez

2206

14126

Ensembl

ENSG00000149534

ENSMUSG00000024680

UniProt

Q01362

P20490

RefSeq (mRNA)

NM_000139
NM_001142303
NM_001256916

NM_001276328
NM_001276329
NM_001276330
NM_013516

RefSeq (protein)

NP_000130
NP_001243845

NP_001263257
NP_001263258
NP_001263259
NP_038544

Location (UCSC)Chr 11: 60.09 – 60.1 MbChr 19: 11.59 – 11.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.[6]

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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