FDX2

FDX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y5C
Identifiers
Aliases	FDX2, ferredoxin 2, FDX1L, ferredoxin 1 like, MEOAL
External IDs	OMIM: 614585 MGI: 1915415 HomoloGene: 31955 GeneCards: FDX2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	10,316,015 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	21,073,614 bp[2]
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; superior frontal gyrus; ; nucleus accumbens; ; hypothalamus; ; substantia nigra; ; temporal lobe; ; hippocampus proper; ; amygdala; ; putamen;
	Top expressed in
	quadriceps femoris muscle; ; white adipose tissue; ; bone marrow; ; muscle tissue; ; proximal tubule; ; skeletal muscle tissue; ; superior frontal gyrus; ; adrenal gland; ; urinary bladder; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron-sulfur cluster binding; protein binding; metal ion binding; 2 iron, 2 sulfur cluster binding; electron transfer activity;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	C21-steroid hormone biosynthetic process; sterol metabolic process; small molecule metabolic process; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	112812
	68165
	ENSG00000267673
	ENSMUSG00000079677
	Q6P4F2
	Q9CPW2
	NM_080665; NM_001031734; NM_001397406
	NM_001039824
	NP_001026904
	NP_001034913
	Wikidata
View/Edit Human	View/Edit Mouse

Ferredoxin 2 is a protein that in humans is encoded by the FDX2 gene. It participates in heme A synthesis and iron-sulphur protein synthesis.[5]

Mutations in FDX2 cause mitochondrial myopathy.[6]

References

GRCh38: Ensembl release 89: ENSG00000267673 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000079677 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ferredoxin 2".
Spiegel R, Saada A, Halvardson J, Soiferman D, Shaag A, Edvardson S, Horovitz Y, Khayat M, Shalev SA, Feuk L, Elpeleg O (July 2014). "Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy". European Journal of Human Genetics. 22 (7): 902–6. doi:10.1038/ejhg.2013.269. PMC 4060119. PMID 24281368.

Sheftel AD, Stehling O, Pierik AJ, Elsässer HP, Mühlenhoff U, Webert H, Hobler A, Hannemann F, Bernhardt R, Lill R (June 2010). "Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 107 (26): 11775–80. Bibcode:2010PNAS..10711775S. doi:10.1073/pnas.1004250107. PMC 2900682. PMID 20547883.

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