Fibrinogen beta chain

Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.

FGB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFGB, HEL-S-78p, fibrinogen beta chain
External IDsOMIM: 134830 MGI: 99501 HomoloGene: 3772 GeneCards: FGB
Orthologs
SpeciesHumanMouse
Entrez

2244

110135

Ensembl

ENSG00000171564

ENSMUSG00000033831

UniProt

P02675

Q8K0E8

RefSeq (mRNA)

NM_001184741
NM_005141

NM_181849

RefSeq (protein)

NP_862897

Location (UCSC)Chr 4: 154.56 – 154.57 MbChr 3: 82.95 – 82.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.[5]

Interactions

Fibrinogen beta chain has been shown to interact with Lipoprotein(a).[6]

See also


References

  1. GRCh38: Ensembl release 89: ENSG00000171564 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033831 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FGB fibrinogen beta chain".
  6. Klose, R; Fresser F; Kochl S; Parson W; Kapetanopoulos A; Fruchart-Najib J; Baier G; Utermann G (December 2000). "Mapping of a minimal apolipoprotein(a) interaction motif conserved in fibrin(ogen) beta - and gamma -chains". J. Biol. Chem. UNITED STATES. 275 (49): 38206–12. doi:10.1074/jbc.M003640200. ISSN 0021-9258. PMID 10980194.

Further reading

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