FGF-2 internal ribosome entry site (IRES)
The FGF-2 internal ribosome entry site is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-2. It has been found that the FGF-2 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific. It is thought that translational IRES dependent activation of FGF-2 plays a vital role in embryogenesis and in the adult brain [1]. When expressed the fibroblast growth factor 2 FGF-2 protein plays a pivotal role in cell proliferation, differentiation and survival as well as being involved in wound-healing [1,2].
| FGF-2 internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_FGF2 | |
| Identifiers | |
| Symbol | IRES_FGF2 |
| Alt. Symbols | IRES_FGF; FGF_IRES |
| Rfam | RF00224 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
References
Further reading
- Créancier L, Morello D, Mercier P, Prats AC (July 2000). "Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation". The Journal of Cell Biology. 150 (1): 275–281. doi:10.1083/jcb.150.1.275. PMC 2185555. PMID 10893274.
- Vagner S, Gensac MC, Maret A, Bayard F, Amalric F, Prats H, Prats AC (January 1995). "Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes". Molecular and Cellular Biology. 15 (1): 35–44. doi:10.1128/mcb.15.1.35. PMC 231905. PMID 7799942.
External links
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