FIBP

Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.[5][6]

FIBP
Identifiers
AliasesFIBP, FGFIBP-1, FGF1 intracellular binding protein, TROFAS
External IDsOMIM: 608296 MGI: 1926233 HomoloGene: 3106 GeneCards: FIBP
Orthologs
SpeciesHumanMouse
Entrez

9158

58249

Ensembl

ENSG00000172500

ENSMUSG00000024911

UniProt

O43427

Q9JI19

RefSeq (mRNA)

NM_004214
NM_198897

NM_001253832
NM_021438

RefSeq (protein)

NP_004205
NP_942600

NP_001240761
NP_067413

Location (UCSC)Chr 11: 65.88 – 65.89 MbChr 19: 5.51 – 5.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

FIBP has been shown to interact with FGF1.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000172500 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024911 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kolpakova, E; Wiedłocha, A; Stenmark, H; Klingenberg, O; Faines, PO; Olsnes, S (15 November 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". Biochem. J. 336 (1): 213–22. doi:10.1042/bj3360213. PMC 1219860. PMID 9806903.
  6. "Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein". ncbi.nlm.nih.gov.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.