FLOT1

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.[5]

FLOT1
Identifiers
AliasesFLOT1, flotillin 1
External IDsOMIM: 606998 MGI: 1100500 HomoloGene: 31337 GeneCards: FLOT1
Orthologs
SpeciesHumanMouse
Entrez

10211

14251

Ensembl

ENSMUSG00000059714

UniProt

O75955

O08917

RefSeq (mRNA)

NM_005803
NM_001318875

NM_008027

RefSeq (protein)

NP_001305804
NP_005794

NP_032053

Location (UCSC)Chr 6: 30.73 – 30.74 MbChr 17: 36.13 – 36.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.[6] The function of flotillin 1 has not been determined.[5]

Interactions

FLOT1 has been shown to interact with SORBS1.[7][8][9]

References

  1. ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 GRCh38: Ensembl release 89: ENSG00000137312, ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059714 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FLOT1 flotillin 1".
  6. Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235.
  7. Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
  8. Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060. S2CID 4334519.
  9. Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.

Further reading


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