FLRT2

FLRT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V2C, 4V2D
Identifiers
Aliases	FLRT2, fibronectin leucine rich transmembrane protein 2
External IDs	OMIM: 604807 MGI: 3603594 HomoloGene: 8291 GeneCards: FLRT2
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	85,654,428 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	95,751,989 bp[2]
RNA expression pattern
	Top expressed in
	germinal epithelium; ; parietal pleura; ; middle temporal gyrus; ; retinal pigment epithelium; ; spinal ganglia; ; Brodmann area 23; ; trigeminal ganglion; ; body of pancreas; ; tibia; ; stromal cell of endometrium;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; sciatic nerve; ; vas deferens; ; hand; ; conjunctival fornix; ; iris; ; renal corpuscle; ; medullary collecting duct; ; trigeminal ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; fibroblast growth factor receptor binding; protein kinase inhibitor activity; chemorepellent activity;
Cellular component	cytoplasm; organelle membrane; integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; cell-cell junction; focal adhesion; synapse; integral component of plasma membrane; extracellular region; cell junction; endoplasmic reticulum; neuron projection; extracellular exosome; plasma membrane; extracellular space; extracellular matrix;
Biological process	negative chemotaxis; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; cell adhesion involved in heart morphogenesis; heart morphogenesis; axon guidance; multicellular organism development; cell adhesion; basement membrane organization; regulation of neuron migration; negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of synapse assembly; fibroblast growth factor receptor signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
	23768
	399558
	ENSG00000185070
	ENSMUSG00000047414
	O43155
	Q8BLU0
	NM_001346143; NM_001346144; NM_001346145; NM_001346146; NM_013231
	NM_201518
	NP_001333072; NP_001333073; NP_001333074; NP_001333075; NP_037363
	NP_958926
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.[5][6][7]

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix.[7]

References

GRCh38: Ensembl release 89: ENSG00000185070 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047414 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lacy SE, Bönnemann CG, Buzney EA, Kunkel LM (December 1999). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.
Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW (September 2006). "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development". Developmental Biology. 297 (1): 14–25. doi:10.1016/j.ydbio.2006.04.004. PMID 16872596.
"Entrez Gene: FLRT2 fibronectin leucine rich transmembrane protein 2".

Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185070 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047414 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10644439-5] Lacy SE, Bönnemann CG, Buzney EA, Kunkel LM (December 1999). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.

[pmid16872596-6] Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW (September 2006). "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development". Developmental Biology. 297 (1): 14–25. doi:10.1016/j.ydbio.2006.04.004. PMID 16872596.

[entrez-7] "Entrez Gene: FLRT2 fibronectin leucine rich transmembrane protein 2".

FLRT2

Function

References

Further reading