FLVCR1

FLVCR1
Identifiers
Aliases	FLVCR1, AXPC1, FLVCR, MFSD7B, PCA, PCARP, feline leukemia virus subgroup C cellular receptor 1, SLC49A1, FLVCR heme transporter 1
External IDs	OMIM: 609144 MGI: 2444881 HomoloGene: 56661 GeneCards: FLVCR1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	212,899,363 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	190,758,355 bp[2]
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; pancreatic epithelial cell; ; corpus epididymis; ; bronchial epithelial cell; ; duodenum; ; germinal epithelium; ; pylorus; ; retinal pigment epithelium; ; tibia; ; cancellous bone;
	Top expressed in
	ciliary body; ; temporal muscle; ; triceps brachii muscle; ; intercostal muscle; ; ileum; ; digastric muscle; ; sexually immature organism; ; seminal vesicula; ; sternocleidomastoid muscle; ; iris;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; protein binding; heme transmembrane transporter activity; heme binding;
Cellular component	integral component of membrane; mitochondrial membrane; membrane; plasma membrane; integral component of plasma membrane; mitochondrion;
Biological process	embryonic skeletal system morphogenesis; head morphogenesis; limb morphogenesis; multicellular organism growth; embryonic digit morphogenesis; in utero embryonic development; mitochondrial transport; spleen development; heme transport; multicellular organism development; blood vessel development; erythrocyte differentiation; regulation of organ growth; heme export; cellular iron ion homeostasis; erythrocyte maturation; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	28982
	226844
	ENSG00000162769
	ENSMUSG00000066595
	Q9Y5Y0
	B2RXV4
	NM_014053
	NM_001081259; NM_001313747; NM_198025
	NP_054772
	NP_001074728; NP_001300676; NP_932142
	Wikidata
View/Edit Human	View/Edit Mouse

Feline leukemia virus subgroup C receptor-related protein 1 is a protein that in humans is encoded by the FLVCR1 gene (SLC49A1).[5][6][7][8]

References

GRCh38: Ensembl release 89: ENSG00000162769 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000066595 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. doi:10.1128/JVI.73.8.6500-6505.1999. PMC 112732. PMID 10400745.
Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. doi:10.1182/blood.V95.3.1093.003k01_1093_1099. PMID 10648427.
"Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".
Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication (6): 400–423. doi:10.1038/nrd.2016.248. ISSN 1474-1784. PMC 5455971. PMID 28154410.

Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG (2002). "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus". Gene. 286 (2): 203–13. doi:10.1016/S0378-1119(02)00457-2. PMID 11943475.
Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004). "Identification of a human heme exporter that is essential for erythropoiesis". Cell. 118 (6): 757–66. doi:10.1016/j.cell.2004.08.014. PMID 15369674. S2CID 12749187.
Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL (2006). "Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia". Blood Cells Mol. Dis. 35 (2): 189–92. doi:10.1016/j.bcmd.2005.01.005. PMID 15996880.
Brown JK, Fung C, Tailor CS (2006). "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1". J. Virol. 80 (4): 1742–51. doi:10.1128/JVI.80.4.1742-1751.2006. PMC 1367145. PMID 16439531.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162769 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066595 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10400745-5] Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. doi:10.1128/JVI.73.8.6500-6505.1999. PMC 112732. PMID 10400745.

[pmid10648427-6] Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. doi:10.1182/blood.V95.3.1093.003k01_1093_1099. PMID 10648427.

[entrez-7] "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".

[8] Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication (6): 400–423. doi:10.1038/nrd.2016.248. ISSN 1474-1784. PMC 5455971. PMID 28154410.

FLVCR1

References

Further reading