FMNL3

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.[5][6]

FMNL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFMNL3, FHOD3, WBP-3, WBP3, FRL2, formin like 3
External IDsOMIM: 616288 MGI: 109569 HomoloGene: 69101 GeneCards: FMNL3
Orthologs
SpeciesHumanMouse
Entrez

91010

22379

Ensembl

ENSG00000161791

ENSMUSG00000023008

UniProt

Q8IVF7

Q6ZPF4

RefSeq (mRNA)

NM_175736
NM_198900
NM_001367835

NM_011711
NM_001310622
NM_001310623

RefSeq (protein)

NP_783863
NP_944489
NP_001354764

NP_001297551
NP_001297552
NP_035841

Location (UCSC)Chr 12: 49.64 – 49.71 MbChr 15: 99.22 – 99.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.[5] The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif.[7] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000161791 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023008 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: formin-like 3".
  6. Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
  7. Heimsath EG, Higgs HN (Jan 2012). "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends". The Journal of Biological Chemistry. 287 (5): 3087–98. doi:10.1074/jbc.M111.312207. PMC 3270965. PMID 22094460.
  8. Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation". Nature Structural & Molecular Biology. 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC 3876896. PMID 23222643.

Further reading


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