FOLR2

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.[5][6][7]

FOLR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1
External IDsOMIM: 136425 MGI: 95569 HomoloGene: 627 GeneCards: FOLR2
Orthologs
SpeciesHumanMouse
Entrez

2350

14276

Ensembl

ENSG00000165457

ENSMUSG00000032725

UniProt

P14207

Q05685

RefSeq (mRNA)

NM_000803
NM_001113534
NM_001113535
NM_001113536

NM_008035
NM_001303231
NM_001303239

RefSeq (protein)

NP_000794
NP_001107006
NP_001107007
NP_001107008

NP_001290160
NP_001290168
NP_032061

Location (UCSC)Chr 11: 72.22 – 72.22 MbChr 7: 101.49 – 101.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000165457 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032725 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kawasaki K, Fearnhead RW (Sep 1975). "On the relationship between tetracycline and the incremental lines in dentine". J Anat. 119 (Pt 1): 49–59. PMC 1231614. PMID 1133088.
  6. van Heyningen V, Little PF (May 1995). "Report of the fourth international workshop on human chromosome 11 mapping 1994". Cytogenet Cell Genet. 69 (3–4): 127–58. doi:10.1159/000133953. PMID 7698003.
  7. "Entrez Gene: FOLR2 folate receptor 2 (fetal)".

Further reading


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