FZR1

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.[5][6][7][8]

FZR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
External IDsOMIM: 603619 MGI: 1926790 HomoloGene: 9444 GeneCards: FZR1
Orthologs
SpeciesHumanMouse
Entrez

51343

56371

Ensembl

ENSG00000105325

ENSMUSG00000020235

UniProt

Q9UM11

Q9R1K5

RefSeq (mRNA)

NM_001136197
NM_001136198
NM_016263

NM_019757

RefSeq (protein)

NP_001129669
NP_001129670
NP_057347

NP_062731

Location (UCSC)Chr 19: 3.51 – 3.54 MbChr 10: 81.2 – 81.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

FZR1 has been shown to interact with CDC27[9][10] and FBXO5.[11]

References
  1. GRCh38: Ensembl release 89: ENSG00000105325 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020235 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kramer, Edgar R.; Gieffers, Christian; Hölzl, Gabriele; Hengstschläger, Markus; Peters, Jan-Michael (1998-11-05). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–S4. doi:10.1016/S0960-9822(07)00510-6. ISSN 0960-9822. PMID 9811605. S2CID 17181162.
  6. Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Molecular Cell. 2 (2): 163–71. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353.
  7. Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (October 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Molecular and Cellular Biology. 20 (20): 7613–23. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321. PMID 11003657.
  8. "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)".
  9. Zhou Y, Ching YP, Ng RW, Jin DY (September 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". The Biochemical Journal. 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC 1223613. PMID 12797865.
  10. Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (November 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–10. doi:10.1016/S0960-9822(07)00510-6. PMID 9811605. S2CID 17181162.
  11. Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. S2CID 25403043.

Further reading
  • Overview of all the structural information available in the PDB for UniProt: Q9UM11 (Fizzy-related protein homolog) at the PDBe-KB.
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