Farnesyl-diphosphate farnesyltransferase 1

Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. [5]

FDFT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFDFT1, DGPT, ERG9, SQS, SS, farnesyl-diphosphate farnesyltransferase 1, SQSD
External IDsOMIM: 184420 MGI: 102706 HomoloGene: 3281 GeneCards: FDFT1
Orthologs
SpeciesHumanMouse
Entrez

2222

14137

Ensembl

ENSG00000079459
ENSG00000284967

ENSMUSG00000021273

UniProt

P37268
Q6IAX1

P53798

RefSeq (mRNA)

NM_010191
NM_001360211

RefSeq (protein)

NP_034321
NP_001347140

Location (UCSC)Chr 8: 11.8 – 11.84 MbChr 14: 63.38 – 63.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

References

  1. ENSG00000284967 GRCh38: Ensembl release 89: ENSG00000079459, ENSG00000284967 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021273 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Farnesyl-diphosphate farnesyltransferase 1". Retrieved 2016-06-25.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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