Fast endophilin-mediated endocytosis

Fast endophilin-mediated endocytosis (FEME) is an endocytic pathway found in eukaryotic cells. It requires the activity of endophilins as well as dynamins, but does not require clathrin.[1]

In Clathrin-dependent endocytic pathways, endosomes budding from the cell membrane into the cell will form in clathrin pits, and be coated by clathrin triskelions. In FEME however, endosomes form when coated by actin, and internalise endophilin A2.

Function

Each endocytic pathway focuses on a particular component, and FEME is primarily involved in transporting receptors. These include receptors for acetylcholine and IL-2.[2]

Associated proteins

References
  1. Casamento A, Boucrot E (June 2020). "Molecular mechanism of Fast Endophilin-Mediated Endocytosis". The Biochemical Journal. 477 (12): 2327–2345. doi:10.1042/bcj20190342. PMC 7319585. PMID 32589750.
  2. Rennick JJ, Johnston AP, Parton RG (March 2021). "Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics". Nature Nanotechnology. 16 (3): 266–276. Bibcode:2021NatNa..16..266R. doi:10.1038/s41565-021-00858-8. PMID 33712737. S2CID 232215301.
  3. Boucrot, Emmanuel; Ferreira, Antonio P. A.; Almeida-Souza, Leonardo; Debard, Sylvain; Vallis, Yvonne; Howard, Gillian; Bertot, Laetitia; Sauvonnet, Nathalie; McMahon, Harvey T. (January 2015). "Endophilin marks and controls a clathrin-independent endocytic pathway". Nature. 517 (7535): 460–465. Bibcode:2015Natur.517..460B. doi:10.1038/nature14067. ISSN 0028-0836. PMID 25517094. S2CID 4470056.


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