Tyrosine-protein kinase Fes/Fps

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.[5][6] FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.[7]

FES
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFES, FPS, Feline sarcoma oncogene, FES proto-oncogene, tyrosine kinase
External IDsOMIM: 190030 MGI: 95514 HomoloGene: 37563 GeneCards: FES
Orthologs
SpeciesHumanMouse
Entrez

2242

14159

Ensembl

ENSG00000182511

ENSMUSG00000053158

UniProt

P07332

P16879

RefSeq (mRNA)

NM_001143783
NM_001143784
NM_001143785
NM_002005

NM_010194

RefSeq (protein)

NP_001137255
NP_001137256
NP_001137257
NP_001996

NP_034324

Location (UCSC)Chr 15: 90.88 – 90.9 MbChr 7: 80.03 – 80.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[8]

Interactions

Feline sarcoma oncogene has been shown to interact with BCAR1[9] and BCR gene.[10][11]

References
  1. GRCh38: Ensembl release 89: ENSG00000182511 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053158 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bowden DW, Akots G, Rothschild CB (Aug 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Research. 19 (15): 4311. doi:10.1093/nar/19.15.4311. PMC 328602. PMID 1870997.
  6. "FES - Tyrosine-protein kinase Fes/Fps - Homo sapiens (Human) - FES gene & protein". www.uniprot.org. Retrieved 16 May 2022.
  7. Craig AW (2012). "FES/FER kinase signaling in hematopoietic cells and leukemias". Frontiers in Bioscience. 17 (3): 861–75. doi:10.2741/3961. PMID 22201778.
  8. "Entrez Gene: FES feline sarcoma oncogene".
  9. Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA (Jan 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". The Journal of Biological Chemistry. 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. PMID 8999909.
  10. Lionberger JM, Smithgall TE (Feb 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Research. 60 (4): 1097–103. PMID 10706130.
  11. Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE (Feb 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and Cellular Biology. 15 (2): 835–42. doi:10.1128/MCB.15.2.835. PMC 231961. PMID 7529874.

Further reading
  • Overview of all the structural information available in the PDB for UniProt: P07332 (Tyrosine-protein kinase Fes/Fps) at the PDBe-KB.


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