Sodium ferric gluconate complex

Sodium ferric gluconate complex, sold under the brand name Ferrlecit, is an intravenously administered iron medication for the treatment of iron deficiency anemia in adults and in children aged six years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy.[1] The macromolecule has an apparent molecular weight of 289,000 – 440,000 Dalton.[2][3]

Sodium ferric gluconate complex
Clinical data
Trade namesFerrlecit
AHFS/Drugs.comMonograph
MedlinePlusa614030
License data
Routes of
administration		Intravenous (IV)
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC66H121Fe2NaO65
Molar mass2089.309 g·mol−1
3D model (JSmol)
  • O[C@H]([C@@H](O)C(O[Na])=O)[C@H](O)[C@H](O)CO.O[C@H]([C@@H](O)C(O1)=O)[C@H](O)[C@H](O)CO.[Fe]1(OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
  • InChI=1S/5C12H22O11.C6H12O7.2Fe.Na.3O/c5*13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12;7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;/h5*4-11,13-20H,1-3H2;2-5,7-11H,1H2,(H,12,13);;;;;;/q;;;;;;2*+3;+1;3*-2/p-1/t5*4-,5-,6-,7-,8+,9-,10+,11-,12+;2-,3-,4+,5-;;;;;;/m111111....../s1
  • Key:MQBDAEHWGRMADS-XNHLMZCASA-M

The most common side effects in adults are nausea, vomiting and/or diarrhea, injection site reaction, hypotension, cramps, hypertension, dizziness, dyspnea, chest pain, leg cramps, and pain.[1] In children the most common side effects are hypotension, headache, hypertension, tachycardia and vomiting.[1]

References
  1. "Ferrlecit- sodium ferric gluconate complex injection". DailyMed. 25 September 2019. Retrieved 2 April 2020.
  2. "Sodium ferric gluconate complex". www.drugbank.ca. Retrieved 21 June 2020.
  3. Fishbane S, Wagner J (May 2001). "Sodium ferric gluconate complex in the treatment of iron deficiency for patients on dialysis". American Journal of Kidney Diseases. 37 (5): 879–83. doi:10.1016/s0272-6386(05)80001-0. PMID 11325667.


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