ADAM2
Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin[5] is an enzyme that in humans is encoded by the ADAM2 gene.[6][7][8]
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| Aliases | ADAM2, CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, ADAM metallopeptidase domain 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601533 MGI: 1340894 HomoloGene: 1127 GeneCards: ADAM2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[8] The other subunit is ADAM1 or alpha-fertilin.[5]
References
- ENSG00000276286 GRCh38: Ensembl release 89: ENSG00000104755, ENSG00000276286 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000022039 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9: 96. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.
- Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389.
- Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.
- "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".
Further reading
- Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y (May 2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions". The Journal of Biological Chemistry. 277 (20): 17804–10. doi:10.1074/jbc.M200086200. PMID 11882657.
- Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M (December 2001). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility". Developmental Biology. 240 (1): 254–61. doi:10.1006/dbio.2001.0462. PMID 11784061.
- Cho C, Ge H, Branciforte D, Primakoff P, Myles DG (June 2000). "Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion". Developmental Biology. 222 (2): 289–95. doi:10.1006/dbio.2000.9703. PMID 10837118.
- Chen MS, Tung KS, Coonrod SA, Takahashi Y, Bigler D, Chang A, Yamashita Y, Kincade PW, Herr JC, White JM (October 1999). "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11830–5. Bibcode:1999PNAS...9611830C. doi:10.1073/pnas.96.21.11830. PMC 18372. PMID 10518536.
- Chen H, Sampson NS (January 1999). "Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta". Chemistry & Biology. 6 (1): 1–10. doi:10.1016/S1074-5521(99)80015-5. PMID 9889149.
- Vidaeus CM, von Kapp-Herr C, Golden WL, Eddy RL, Shows TB, Herr JC (March 1997). "Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member". Molecular Reproduction and Development. 46 (3): 363–9. doi:10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-#. PMID 9041139. S2CID 196584546.
- Dawson SJ, White LA (May 1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". The Journal of Infection. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.950
- Human ADAM2 genome location and ADAM2 gene details page in the UCSC Genome Browser.
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