Flavanone 3-dioxygenase
In enzymology, a flavanone 3-dioxygenase (EC 1.14.11.9) is an enzyme that catalyzes the chemical reaction
- a flavanone + 2-oxoglutarate + O2 a dihydroflavonol + succinate + CO2
| naringenin 3-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.11.9 | ||||||||
| CAS no. | 75991-43-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are flavanone, 2-oxoglutarate, and O2, whereas its 3 products are dihydroflavonol, succinate, and CO2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). Other names in common use include naringenin 3-hydroxylase, flavanone 3-hydroxylase, flavanone 3beta-hydroxylase, flavanone synthase I, (2S)-flavanone 3-hydroxylase, and naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). This enzyme participates in flavonoid biosynthesis. It has 2 cofactors: iron, and Ascorbate.
References
- Forkmann G, Heller W, Grisebach H (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3- and flavonoid 3'-hydroxylases". Z. Naturforsch. C: Biosci. 35: 691–695.
- Wellmann F, Matern U, Lukacin R (2004). "Significance of C-terminal sequence elements for Petunia flavanone 3beta-hydroxylase activity". FEBS Lett. 561 (1–3): 149–54. doi:10.1016/S0014-5793(04)00159-0. PMID 15013767.