Flusilazole

Flusilazole (DPX-H6573) is an organosilicon fungicide invented by DuPont, which is used to control fungal infections on a variety of fruit and vegetable crops.[1][2][3] It is moderately toxic to animals and has been shown to produce birth defects in high doses.[4][5]

Flusilazole
Names
Preferred IUPAC name
1-{[Bis(4-fluorophenyl)(methyl)silyl]methyl}-1H-1,2,4-triazole
Other names
DPX-H6573;
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.107.525
UNII
  • InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3 ☒N
    Key: FQKUGOMFVDPBIZ-UHFFFAOYSA-N ☒N
  • InChI=1/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3
    Key: FQKUGOMFVDPBIZ-UHFFFAOYAI
  • c2ncnn2C[Si](C)(c(cc1)ccc1F)c3ccc(F)cc3
Properties
C16H15F2N3Si
Molar mass 315.392 g/mol
41.9 mg/L (20°C)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

References
  1. Moberg, W. K.; Basarab, G. S.; Cuomo, J.; Liang, P. H. (1987). "Biologically Active Organosilicon Compounds". Synthesis and Chemistry of Agrochemicals. ACS Symposium Series. Vol. 355. pp. 288–301. doi:10.1021/bk-1987-0355.ch026. ISBN 9780841214347.
  2. Bostanian NJ, Larocque N, Chouinard G, Coderre D (November 2001). "Baseline toxicity of several pesticides to Hyaliodes vitripennis (Say) (Hemiptera: Miridae)". Pest Management Science. 57 (11): 1007–10. doi:10.1002/ps.374. PMID 11721516.
  3. Eckert MR, Rossall S, Selley A, Fitt BD (April 2010). "Effects of fungicides on in vitro spore germination and mycelial growth of the phytopathogens Leptosphaeria maculans and L. biglobosa (phoma stem canker of oilseed rape)". Pest Management Science. 66 (4): 396–405. doi:10.1002/ps.1890. PMID 20013877.
  4. Farag AT, Ibrahim HH (February 2007). "Developmental toxic effects of antifungal flusilazole administered by gavage to mice". Birth Defects Research Part B: Developmental and Reproductive Toxicology. 80 (1): 12–7. doi:10.1002/bdrb.20098. PMID 17187383.
  5. Hermsen SA, van den Brandhof EJ, van der Ven LT, Piersma AH (January 2011). "Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies". Toxicology in Vitro. 25 (3): 745–753. doi:10.1016/j.tiv.2011.01.005. PMID 21238576.
  • Flusilazole in the Pesticide Properties DataBase (PPDB)


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