Folipastatin

Folipastatin is a depsidone phospholipase A2 inhibitor which is produced by the fungi Aspergillus unguis and Wicklowia aquatica.[2][3][1] Folipastatin has the molecular formula C23H24O5.[1]

Folipastatin
Names
IUPAC name
1,7-bis[(Z)-but-2-en-2-yl]-3,9-dihydroxy-4,10-dimethylbenzo[b][1,4]benzodioxepin-6-one[1]
Other names
E323392EAO
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C23H24O5/c1-7-11(3)15-9-17(24)13(5)20-19(15)23(26)28-21-14(6)18(25)10-16(12(4)8-2)22(21)27-20/h7-10,24-25H,1-6H3/b11-7-,12-8-
    Key: JJMKBGPTPXPMBH-OXAWKVHCSA-N
  • C/C=C(/C)\C1=CC(=C(C2=C1C(=O)OC3=C(O2)C(=CC(=C3C)O)/C(=C\C)/C)C)O
Properties
C23H24O5
Molar mass 380.440 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. "Folipastatin". Pubchem.ncbi.NLM.nih.gov.
  2. Hamano, Kiyoshi; Kinoshita-Okami, Masako; Hemmi, Atsuko; Sato, Akira; Hisamoto, Marie; Matsuda, Keiichi; Yoda, Keiko; Haruyama, Hideyuki; Hosoya, Tsuyoshi; Tanzawa, Kazuhiko (1992). "Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties". The Journal of Antibiotics. 45 (8): 1195–1201. doi:10.7164/antibiotics.45.1195. PMID 1399838.
  3. Bycroft, Barrie W.; Payne, David J. (9 August 2013). Dictionary of Antibiotics and Related Substances: with CD-ROM, Second Edition. CRC Press. p. 829. ISBN 978-1-4822-8215-3.

Further reading
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