Fractional synthetic rate

A fractional synthetic rate (FSR) is the rate at which a precursor compound is incorporated into a product per unit of product mass.[1] The metric has been used to estimate the rate at which proteins, lipids, and lipoproteins are synthesized within humans and other animals.[1][2] The formula used to calculate the FSR from a stable isotope tracer experiment is:[1]

$FSR={\frac {\color {Blue}{\text{initial rate of change in product enrichment}}}{\color {Green}{\text{initial precursor enrichment}}}}$

References

Foster DM, Barrett PH, Toffolo G, Beltz WF, Cobelli C (1993). "Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable isotope data" (PDF). J. Lipid Res. 34 (12): 2193–2205. PMID 8301238.
Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ (June 2013). "Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism" (PDF). J. Physiol. 591 (11): 2911–2923. doi:10.1113/jphysiol.2013.253203. PMC 3690694. PMID 23551944.

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[pmid8301238-1] Foster DM, Barrett PH, Toffolo G, Beltz WF, Cobelli C (1993). "Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable isotope data" (PDF). J. Lipid Res. 34 (12): 2193–2205. PMID 8301238.

[HMB_in_vivo_human_pharmacodynamics-2] Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ (June 2013). "Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism" (PDF). J. Physiol. 591 (11): 2911–2923. doi:10.1113/jphysiol.2013.253203. PMC 3690694. PMID 23551944.