Frederick Alt

Frederick W. Alt is an American geneticist. He is a member of the Immunology section of the National Academy of Sciences and a Charles A. Janeway Professor of Pediatrics, and Professor of Genetics at Harvard Medical School.[1] He is the Director of the Program in Cellular and Molecular Medicine at the Boston Children's Hospital.[2] He is a Howard Hughes Medical Institute investigator, since 1987.

Frederick Alt
Other namesFred Alt
Alma mater
Scientific career
Institutions
Doctoral studentsKaren M. Frank

Career

Alt completed his undergraduate studies at Brandeis University, graduating in 1971.[3] He then went on to earn a Ph.D. in Biology from Stanford University in 1977 while under the research direction of Robert Schimke. He performed his postdoctoral work in David Baltimore's laboratory at Massachusetts Institute of Technology (MIT).[4] From 1982 to 1991 he was on the faculty at Columbia University and then moved to Harvard Medical School.[5]

Alt's research interest is in maintenance of genome stability in cells of the mammalian immunological system, particularly antigen receptor variable region gene assembly in developing B and T lymphocytes, immunoglobulin heavy chain class switch recombination (CSR), and somatic hypermutation in activated mature B lymphocytes.[1]

Personal life

Alt is the son-in-law of the organic chemist, Koji Nakanishi, who served as Centennial Professor of Chemistry and chair of the Chemistry Department at Columbia University.[6]

Alt is also the father of the chef and food writer, J. Kenji López-Alt.[7]

Awards, memberships and honors

He has received many awards, this is a select list:

The Cancer Research Institute of New York gives an annual prize in his honor, the Frederick W. Alt Award for New Discoveries in Immunology.

Alt is a member of:

References
  1. Dana-Farber profile
  2. "How new loops in DNA packaging help us make diverse antibodies". phys.org. Retrieved November 14, 2019.
  3. "Pioneering geneticist Frederick Alt '71 wins 44th Rosenstiel Award". BrandeisNOW. Retrieved November 14, 2019.
  4. "Alt Laboratory". www.childrenshospital.org. Retrieved December 29, 2022.
  5. "Children's Hospital bio". Archived from the original on January 20, 2018. Retrieved September 10, 2011.
  6. "J. Kenji López-Alt: Seattle's Famous Japanese American Cooking Star". The North American Post. September 23, 2022. Archived from the original on October 6, 2022. Retrieved December 9, 2022.
  7. Robertson, Blair Anthony (2015). "Science becomes delicious in 'The Food Lab'". The Sacramento Bee. Archived from the original on December 16, 2015. Retrieved November 13, 2019. His father, Frederick Alt, is a professor at Harvard Medical School
  8. "Laureates". Novartis Prizes for Immunology. August 29, 2018. Archived from the original on August 29, 2018. Retrieved November 14, 2019.
  9. "CRI Announces Winner of 2009 Frederick Alt Award for New Discoveries in Immunology". Cancer Research Institute. Retrieved November 14, 2019.
  10. Scully, Peter; Zhao, Jie; Ba, Sujuan (February 3, 2016). "Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research". Chinese Journal of Cancer. 35: 17. doi:10.1186/s40880-015-0075-x. ISSN 1000-467X. PMC 4741029. PMID 26843073.
  11. "AAI-BioLegend Herzenberg Award". The American Association of Immunologists, Inc. (AAI).
  12. "AAI Career Awards". Immunology 2019. Retrieved November 14, 2019.
  13. Paul Ehrlich and Ludwig Darmstaedter Prize 2023
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