Friedhelm Hildebrandt

Friedhelm Hildebrandt (born February 11, 1957) is the William E. Harmon Professor of Pediatrics at Harvard Medical School and Chief of the Division of Nephrology at Boston Children's Hospital.[1] He was formerly an Investigator of the Howard Hughes Medical Institute (HHMI) and the Frederick G.L. Huetwell Professor of Pediatrics at the University of Michigan.[2][3]

Early life and education

Hildebrandt received his M.D. degree from Heidelberg University (Germany), obtained his pediatrics and nephrology subspecialty training at Marburg University Children's Hospital, and was a postdoctoral research fellow in nephrology at Yale School of Medicine (Peter Aronson & Peter Igarashi).

Research

Friedhelm Hildebrandt identified and functionally characterized multiple kidney diseases caused by single-genes (Mendelian) including nephrotic syndrome, cystic renal ciliopathies,[4] and congenital anomalies of the kidney [5]

Hildebrandt was elected to the American National Academy of Medicine in 2015,[6] Leopoldina in 2007,[7] and to the Association of American Physicians in 2005.[8] He is a recipient of the Homer Smith Award of the American Society of Nephrology (2014),[9] the Alfred R. Newton Award of the International Society of Nephrology (ISN) (2017),[10] and the E. Mead Johnson Award[11] from the Society for Pediatric Research (2004).

Hildebrandt’s group has identified over 80 novel causative genes of the 240 genes that are currently known to cause chronic kidney disease, if mutated.[12] His laboratory delineated the related disease mechanisms by generating animal models of human kidney disease in mice, zebrafish, C. elegans, and Drosophila as well in cell-based systems. He demonstrated that in a very high percentage of cases with early-onset chronic kidney disease a single-gene cause may be identified.[13][14] Link to pertinent publications.[12]

References

  1. "BCH Division of Nephrology". BCH Division of Nephrology Hildebrandt. Retrieved 29 March 2020.
  2. "HHMI". HHMI - Hildebrandt. HHMI. Retrieved 29 March 2020.
  3. "UoM" (PDF). UoM Hildebrandt. University of Michigan. Retrieved 29 March 2020.
  4. Hildebrandt, F; Benzing, T; Katsanis, N (21 April 2011). "Ciliopathies". The New England Journal of Medicine. 364 (16): 1533–43. doi:10.1056/NEJMra1010172. PMC 3640822. PMID 21506742.
  5. Vivante, A; Hildebrandt, F (March 2016). "Exploring the genetic basis of early-onset chronic kidney disease". Nature Reviews. Nephrology. 12 (3): 133–46. doi:10.1038/nrneph.2015.205. PMC 5202482. PMID 26750453.
  6. "National Academy of Medicine". National Academy of Medicine - Hildebrandt. Retrieved 29 March 2020.
  7. "Leopoldina". Leopoldina - Hildebrandt. Retrieved 29 March 2020.
  8. Association of American Physicians. AAP https://aap-online.org/. Retrieved 29 March 2020. {{cite web}}: Missing or empty |title= (help)
  9. "ASN - Homer Smith Award". Homer Smoth W. Award. American Society of Nephrology. Retrieved 29 March 2020.
  10. "ISN Awards". A.N. Richards Award. International Society of Nephrology. Retrieved 29 March 2020.
  11. "Past Award Recipients". E. Mead Johnson Award. Society for Pediatric Research. Retrieved 29 March 2020.
  12. Search Results for author Hildebrandt F on PubMed.
  13. Sadowski, Carolin E.; Lovric, Svjetlana; Ashraf, Shazia; Pabst, Werner L.; Gee, Heon Yung; Kohl, Stefan; Engelmann, Susanne; Vega-Warner, Virginia; Fang, Humphrey; Halbritter, Jan; Somers, Michael J.; Tan, Weizhen; Shril, Shirlee; Fessi, Inès; Lifton, Richard P.; Bockenhauer, Detlef; El-Desoky, Sherif; Kari, Jameela A.; Zenker, Martin; Kemper, Markus J.; Mueller, Dominik; Fathy, Hanan M.; Soliman, Neveen A.; Hildebrandt, Friedhelm (June 2015). "A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome". Journal of the American Society of Nephrology. 26 (6): 1279–1289. doi:10.1681/ASN.2014050489. PMC 4446877. PMID 25349199.
  14. Braun, Daniela A.; Schueler, Markus; Halbritter, Jan; Gee, Heon Yung; Porath, Jonathan D.; Lawson, Jennifer A.; Airik, Rannar; Shril, Shirlee; Allen, Susan J.; Stein, Deborah; Al Kindy, Adila; Beck, Bodo B.; Cengiz, Nurcan; Moorani, Khemchand N.; Ozaltin, Fatih; Hashmi, Seema; Sayer, John A.; Bockenhauer, Detlef; Soliman, Neveen A.; Otto, Edgar A.; Lifton, Richard P.; Hildebrandt, Friedhelm (February 2016). "Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity". Kidney International. 89 (2): 468–475. doi:10.1038/ki.2015.317. PMC 4840095. PMID 26489029.
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