Friedrich Fehleisen

Friedrich Fehleisen (/ˈfeːlaɪ̯sən/) (1854–1924) was a German surgeon whose work focused on streptococcal bacteria. Dr. Fehleisen's work played a necessary role in the eventual uncovering of the etiology of many streptococcal illnesses. He made integral contributions to modern medicine's understanding of the Streptococcus pyogenes organism. He was born in Reutlingen, Württemberg, in 1854, and died in San Francisco, California, in 1924.

S. pyogenes and erysipelas

In 1883, he became the first person to culture and collect Streptococcus pyogenes, which causes scarlet fever and other streptococcal illnesses. He cultured it from perierysipelas lesions on humans. One year later, the organism received its current name from Rosenbach. German physician Friedrich Loeffler subsequently demonstrated the presence of streptococci in the throats of patients with scarlet fever.[1]

Additionally, Dr. Fehleisen uncovered the etiology of erysipelas, which is an acute streptococcal bacterial infection of the upper dermis and superficial lymphatics. His literature "Die Aetiologie Des Erysipels", which was originally published in 1883, outlines his findings.[2]

Cancer immunotherapy

Following his discovery of S. pyogenes being the causative agent of erysipelas, Fehleisen repeated the experiments of the German surgeon Wilhelm Busch, inoculating sarcoma patients with it and then noting regression in many of them.[3] His first patient, a 58-year-old woman with a fibrosarcoma of the gluteus, got a significant remission, although the very high fever of 41°C made Fehleisen question the utility of this method as a therapy.[4]

Fehleisen observations later inspired William Coley to try the method on his patients and eventually developing Coley's toxins.

References
  1. Kim, Luke (2008). "Bacterial Attenuation and its Link to Innate Oncolytic Potential". Answers Research Journal. 1: 117–122.
  2. Fehleisen, Friedrich (2010). Die Aetiologie Des Erysipels. BiblioBazaar. ISBN 978-1-149-67575-5.
  3. Kucerova, Petra; Cervinkova, Monika (April 2016). "Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment". Anti-Cancer Drugs. 27 (4): 269–277. doi:10.1097/CAD.0000000000000337. PMC 4777220. PMID 26813865.
  4. Fehleisen (1882). "Ueber die Züchtung der Erysipelkokken auf künstlichem Nährboden und ihre Uebertragbarkeit auf den Menschen" [On the cultivation of erysipelas cocci on artificial culture medium and their transferability to humans]. Deutsche Medizinische Wochenschrift (in German). 8: 553–554.

Further reading
  • Fehleisen, Friedrich (1883). Die Aetiologie des Erysipels (in German). Theodor Fischer. OCLC 651966080.


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