Fructose-bisphosphatase 2
Fructose-bisphosphatase 2 is an enzyme that in humans is encoded by the FBP2 gene. [5]
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| Aliases | FBP2, fructose-bisphosphatase 2, CORLK | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603027 MGI: 95491 HomoloGene: 55784 GeneCards: FBP2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.[6]
References
- GRCh38: Ensembl release 89: ENSG00000130957 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000021456 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Fructose-bisphosphatase 2". Retrieved 2018-09-14.
- Lee T, Bhushan B, Sochat M (January 2020). first aid for the USMLE Step 1 (Thirtieth ed.). USA: Mc GrawHill. p. 76. ISBN 9781260462043.
Further reading
- Rakus D, Maciaszczyk E, Wawrzycka D, Ułaszewski S, Eschrich K, Dzugaj A (October 2005). "The origin of the high sensitivity of muscle fructose 1,6-bisphosphatase towards AMP". FEBS Letters. 579 (25): 5577–5581. doi:10.1016/j.febslet.2005.09.021. PMID 16213487. S2CID 6931830.
- Gizak A, Maciaszczyk E, Dzugaj A, Eschrich K, Rakus D (July 2008). "Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase". Proteins. 72 (1): 209–216. doi:10.1002/prot.21909. PMID 18214967. S2CID 21403418.
- Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutation Research. 694 (1–2): 13–19. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
- Li H, Wang J, Xu H, Xing R, Pan Y, Li W, et al. (September 2013). "Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells". Molecular Cancer. 12 (1): 110. doi:10.1186/1476-4598-12-110. PMC 3849177. PMID 24063558.
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