Fumarate reductase (NADH)
In enzymology, a fumarate reductase (NADH) (EC 1.3.1.6) is an enzyme that catalyzes the chemical reaction
- succinate + NAD+ fumarate + NADH + H+
| fumarate reductase (NADH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.6 | ||||||||
| CAS no. | 9076-99-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are succinate and NAD+, whereas its three products are fumarate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is succinate:NAD+ oxidoreductase. Other names in common use include NADH-fumarate reductase, NADH-dependent fumarate reductase, and fumarate reductase (NADH).
References
- Hopgood MF, Walker DJ (1969). "Succinic acid production by rumen bacteria. III. Enzymic studies on the formation of succinate by Ruminococcus flavefaciens". Aust. J. Biol. Sci. 22: 1413–1424.
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