Funisitis

Funisitis is inflammation of the connective tissue of the umbilical cord that occurs with chorioamnionitis. It involves only the external cord surface and Wharton's jelly. It has no involvement of the vessels. It does not involve the umbilical stump, which would be seen in omphalitis.

Histopathology of phlebitis (inflammation of a vein, in this case an umbilical vein) and funisitis (inflammation of the connective tissue of the umbilical cord), with neutrophils (high magnification in bottom insert).

Necrotizing funisitis

Necrotizing funisitis is a very severe form of funisitis that occurs when the funisitis has been present for a long time. Debris from inflammatory cells accumulate and the cord becomes calcified. Treatment with IV antibiotics is necessary for necrotizing funisitis, with a minimum of 7 days. This can occur in healthy born infants; the infection occurs in the days and weeks following birth. With IV antibiotic treatment and early management, outcomes are good.[1]

Syphilis association

It could be associated with congenital syphilis, which is noted in a journal from 1999. It is now rare, and seen almost exclusively in the preterm infant. The majority of these affected infants are stillborn, or die within a few weeks of birth.[2]

Treatment

The most common way to treat funisitis is with antibiotics. If you have choriamnionitis, the antibiotics that are most effective are ampicillin and gentamicin. However, if you're allergic to penicillin, you may need to use other antibiotics, such as clindamycin, cefazolin, or vancomycin. After giving birth, the official recommendation is to give one dose of antibiotics with a cesarean section, but this doesn't always happen. If you deliver vaginally, you may need to take antibiotics for a longer period of time, depending on the situation.[3]

See also

References
  1. (2019, June 25). Care of the umbilicus and management of umbilical disorders. Retrieved from https://www.uptodate.com/contents/care-of-the-umbilicus-and-management-of-umbilical-disorders?search=omphalitis&source=search_result&selectedTitle=1~47&usage_type=default&display_rank=1
  2. Singh, Ameeta E.; Barbara Romanowski (April 1999). "Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features". Clinical Microbiology Reviews. 12 (2): 187–209. doi:10.1128/CMR.12.2.187. PMC 88914. PMID 10194456.
  3. Team, Health Jade (2020-08-29). "Funisitis definition, causes, diagnosis, treatment & prognosis". Health Jade. Retrieved 2023-03-04.
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