Fusobacteriota

Fusobacteriota are obligately anaerobic non-sporeforming Gram-negative bacilli. Since the first reports in the late nineteenth century, various names have been applied to these organisms, sometimes with the same name being applied to different species. More recently, not only have there been changes to the nomenclature, but also attempts to differentiate between species which are believed to be either pathogenic or commensal or both. Because of their asaccharolytic nature, and a general paucity of positive results in routine biochemical tests, laboratory identification of the Fusobacteriota has been difficult. However, the application of novel molecular biological techniques to taxonomy has established a number of new species, together with the subspeciation of Fusobacterium necrophorum and F. nucleatum, and provided new methods for identification. The involvement of Fusobacteriota in a wide spectrum of human infections causing tissue necrosis and septicaemia has long been recognised, and, more recently, their importance in intra-amniotic infections, premature labour and tropical ulcers has been reported.

Fusobacteriota
"Fusobacterium novum" in liquid culture
Fusobacterium novum in liquid culture
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Fusobacteriota
Garrity & Holt 2021[1]
Class: Fusobacteriia
Staley & Whitman 2012
Order: Fusobacteriales
Staley & Whitman 2012
Families[2]
Synonyms
  • Fusobacteriota:
    • "Fusobacteria" Garrity and Holt 2001
    • "Fusobacteraeota" Oren et al. 2015
    • "Fusobacteriota" Whitman et al. 2018
  • Fusobacteriia:

Since the first reports of Fusobacteriota in the late nineteenth century, the variety of species names has led to some confusion within the genera Fusobacterium and Leptotrichia. However, newer methods of investigation have led to a better understanding of the taxonomy, with the description of several new species of Fusobacteriota. Among the new species described are F. ulcerans from tropical ulcers, and several species from the oral cavity. Subspeciation of the important species F. necrophorum and F. nucleatum has also been possible. It is probable that the taxonomy of the Fusobacteriota may be further developed in the future.[3]

Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LSPN)[4] and National Center for Biotechnology Information (NCBI).[5]

16S rRNA based LTP_12_2021[6][7][8] 120 single copy marker proteins based GTDB 08-RS214[9][10][11]
Leptotrichiaceae

Leptotrichia Trevisan 1879

Pseudoleptotrichia Eisenberg et al. 2020

Sebaldella Collins and Shah 1986

Caviibacter Eisenberg et al. 2016

Oceanivirga Eisenberg et al. 2016

Sneathia Collins et al. 2002

Pseudostreptobacillus Eisenberg et al. 2020

Streptobacillus Levaditi, Nicolau & Poincloux 1925

Fusobacteriaceae

Hypnocyclicus Roalkvam et al. 2015

Psychrilyobacter Zhao et al. 2009

Ilyobacter insuetus Brune et al. 2002

Ilyobacter Stieb and Schink 1985

Propionigenium Schink & Pfennig 1983

Cetobacterium Foster et al. 1996

Fusobacterium Knorr 1922
Leptotrichiaceae

Sebaldella

Caviibacter

Oceanivirga

Sneathia

Streptobacillus

Pseudoleptotrichia

Leptotrichia

Fusobacteriaceae

Hypnocyclicus

Psychrilyobacter

Ilyobacter

Cetobacterium

Fusobacterium

Role in Human Disease

New evidence is emerging that this bacterium may cause or be related to human colon cancer. In 2011 investigators reported the presence of Fusobacteriota in colon cancer tissue (Genome Res 2012; 22:292) and a new multicenter study provides evidence that some cases-particularly right-sided might be caused by infection by Fusobacteriota.[12]

See also

References
  1. Oren A, Garrity GM (2021). "Valid publication of the names of forty-two phyla of prokaryotes". Int J Syst Evol Microbiol. 71 (10): 5056. doi:10.1099/ijsem.0.005056. PMID 34694987.
  2. "Fusobacteriales". NCBI taxonomy. Bethesda, MD: National Center for Biotechnology Information. Retrieved 3 January 2019.
  3. Bennett, K. W.; Eley, A. (1 October 1993). "Fusobacteria: New taxonomy and related diseases". Journal of Medical Microbiology. 39 (4): 246–254. doi:10.1099/00222615-39-4-246. PMID 8411084.
  4. J.P. Euzéby. "Fusobacteria". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved 2016-03-20.
  5. Sayers; et al. "Fusobacteria". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2016-03-20.
  6. "The LTP". Retrieved 23 February 2021.
  7. "LTP_all tree in newick format". Retrieved 23 February 2021.
  8. "LTP_12_2021 Release Notes" (PDF). Retrieved 23 February 2021.
  9. "GTDB release 08-RS214". Genome Taxonomy Database. Retrieved 10 May 2023.
  10. "bac120_r214.sp_label". Genome Taxonomy Database. Retrieved 10 May 2023.
  11. "Taxon History". Genome Taxonomy Database. Retrieved 10 May 2023.
  12. Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, Chipashvili O, Hagan T, Walker M, Ramachandran A, Diosdado B, Serna G, Mulet N, Landolfi S, Ramon y Cajal S, Fasani R, Aguirre AJ, Ng K, Élez E, Ogino S, Tabernero J, Fuchs CS, Hahn WC, Nuciforo P, Meyerson M. (2017). "Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer". Science. 358 (6369): 1443–1448. Bibcode:2017Sci...358.1443B. doi:10.1126/science.aal5240. PMC 5823247. PMID 29170280.
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