G3BP1

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.[5][6][7]

G3BP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesG3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1
External IDsOMIM: 608431 MGI: 1351465 HomoloGene: 38096 GeneCards: G3BP1
Orthologs
SpeciesHumanMouse
Entrez

10146

27041

Ensembl

ENSG00000145907

ENSMUSG00000018583

UniProt

Q13283

P97855

RefSeq (mRNA)

NM_005754
NM_198395

NM_013716

RefSeq (protein)

NP_005745
NP_938405

NP_038744

Location (UCSC)Chr 5: 151.77 – 151.81 MbChr 11: 55.36 – 55.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]

G3BP1 can initiate stress granule formation and labeled G3BP1 is commonly used as a marker for stress granules.[9]

Interactions

G3BP1 has been shown to interact with USP10.[10] It also interacts with SND1[5].

References

  1. GRCh38: Ensembl release 89: ENSG00000145907 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018583 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. doi:10.1128/MCB.16.6.2561. PMC 231246. PMID 8649363.
  6. Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
  7. "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
  8. Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLOS ONE. 6 (12): e29024. Bibcode:2011PLoSO...629024A. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.
  9. Mahboubi, Hicham; Stochaj, Ursula (2017-04-01). "Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863 (4): 884–895. doi:10.1016/j.bbadis.2016.12.022. ISSN 0925-4439. PMID 28095315.
  10. Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. England. 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350.

[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532.

Further reading


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