Grb2 associated binding protein 3

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. [5]

GAB3
Identifiers
AliasesGAB3, GRB2 associated binding protein 3
External IDsOMIM: 300482 MGI: 2387324 HomoloGene: 15417 GeneCards: GAB3
Orthologs
SpeciesHumanMouse
Entrez

139716

210710

Ensembl

ENSG00000160219

ENSMUSG00000032750

UniProt

Q8WWW8

Q8BSM5

RefSeq (mRNA)

NM_001081573
NM_001282283
NM_080612

NM_181584

RefSeq (protein)

NP_001075042
NP_001269212
NP_542179

NP_853615

Location (UCSC)Chr X: 154.68 – 154.75 MbChr X: 74.01 – 74.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

References

  1. GRCh38: Ensembl release 89: ENSG00000160219 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032750 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 2019-08-03.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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