GAS2

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.[5][6]

GAS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGAS2, growth arrest specific 2, GAS-2
External IDsOMIM: 602835 MGI: 95657 HomoloGene: 31301 GeneCards: GAS2
Orthologs
SpeciesHumanMouse
Entrez

2620

14453

Ensembl

ENSG00000148935

ENSMUSG00000030498

UniProt

O43903

P11862

RefSeq (mRNA)

NM_008087
NM_001330607
NM_001330608

RefSeq (protein)

NP_001137302
NP_005247
NP_808221
NP_001338153

NP_001317536
NP_001317537
NP_032113

Location (UCSC)Chr 11: 22.63 – 22.81 MbChr 7: 51.51 – 51.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000148935 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030498 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.
  6. "Entrez Gene: GAS2 growth arrest-specific 2".

Further reading


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