GCAT

Glycine C-acetyltransferase is a protein that in humans is encoded by the GCAT gene.[3]

GCAT
Identifiers
AliasesGCAT, KBL, glycine C-acetyltransferase
External IDsOMIM: 607422 MGI: 1349389 HomoloGene: 8475 GeneCards: GCAT
Orthologs
SpeciesHumanMouse
Entrez

23464

26912

Ensembl

n/a

ENSMUSG00000006378

UniProt

O75600

O88986

RefSeq (mRNA)

NM_001171690
NM_014291

NM_001161712
NM_013847

RefSeq (protein)

NP_001165161
NP_055106

NP_001155184
NP_038875

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.

GCAT can also be used to refer to Grace Cat, who goes by the nickname of GCAT.

References

  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: Glycine C-acetyltransferase".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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