GDB Human Genome Database

The GDB Human Genome Database was a community curated collection of human genomic data. It was a key database in the Human Genome Project[1][2] and was in service from 1989 to 2008.

GDB Human Genome Database
Content
Data types
captured		Genetic mapping data
OrganismsHomo sapiens
Contact
Research center
Primary citationPMID 2041809
Release date1989

History

In 1989 the Howard Hughes Medical Institute provided funding to establish a central repository for human genetic mapping data. This project ultimately resulted in the creation of the GDB Human Genome DataBase in September 1990.[3][4] In order to ensure a high degree of quality, records within GDB were subjected to a curation process by human genetics specialists, including the HUGO Gene Nomenclature Committee.[5]

Established under the leadership of Peter Pearson and Dick Lucier,[6] GDB received financial support from the US Department of Energy and the National Institutes of Health.[3] Located at the Johns Hopkins University School of Medicine, GDB became a source of high quality mapping data which were made available both online as well as through numerous printed publications. The project was supported internationally by the EU, Japan, and other countries.

The GDB had several directors in its time. Peter Pearson, David T. Kingsbury, Stantley Letovsky, Peter Li, and A. Jamie Cuticchia.

Funds from the US Department of Energy that were previously allocated for GDB were transferred in 1998 due to the shift in emphasis in the human genome project.[7] However that same year, A. Jamie Cuticchia obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children (HSC) in Toronto, Ontario, Canada.[8] In November 2001, the HSC fired Cuticchia due to a dispute over the GDB website domain name.[7]

In 2003 RTI International became the new host for GDB where it continued to be maintained as a public resource;[9] GDB was closed in 2008 after control of the project reverted to Johns Hopkins.[10]

References
  1. "Human Genome News, September-December 1995: 7(3-4):15". web.ornl.gov.
  2. Guyer, M. S.; Collins, F. S. (21 November 1995). "How is the Human Genome Project doing, and what have we learned so far?". Proceedings of the National Academy of Sciences. 92 (24): 10841–10848. Bibcode:1995PNAS...9210841G. doi:10.1073/pnas.92.24.10841. PMC 40527. PMID 7479895.
  3. Cuticchia, A.Jamie; Fasman, Kenneth H.; Kingsbury, David T.; Robbins, Robert J.; Pearson, Peter L. (1993). "The GDB TM human genome data base anno 1993". Nucleic Acids Research. 21 (13): 3003–3006. doi:10.1093/nar/21.13.3003. PMC 309725. PMID 8332522.
  4. Cuticchia, A.J. (27 Dec 1999). "Future vision of the GDB human genome database". Human Mutation. 15 (1): 62–67. doi:10.1002/(SICI)1098-1004(200001)15:1<62::AID-HUMU13>3.0.CO;2-R. PMID 10612824. S2CID 25606440.
  5. Letovsky, S. (1 January 1998). "GDB: the Human Genome Database". Nucleic Acids Research. 26 (1): 94–99. doi:10.1093/nar/26.1.94. PMC 147203. PMID 9399808.
  6. Pearson, P.L. (25 April 1991). "The genome data base (GDB)--a human gene mapping repository". Nucleic Acids Research. 19 (suppl): 2237–2239. doi:10.1093/nar/19.suppl.2237. PMC 331357. PMID 2041809.
  7. Bonetta, Laura (November 2001). "Sackings leave gene database floundering". Nature. 414 (6862): 384. Bibcode:2001Natur.414..384B. doi:10.1038/35106703. PMID 11719765.
  8. "Human Genome News Vol.10,No.1-2, February 1999". web.ornl.gov. Retrieved 3 September 2020.
  9. Seewald, A.K. (2004). "Ranking for BioMinT: investigating performance, local search and homonymy recognition". Proceedings of the Symposium on Knowledge Exploration in Life Science Informatics (KELSI 2004). CiteSeerX 10.1.1.117.8840. doi:10.1007/978-3-540-30478-4_10.
  10. Galperin, M. Y.; Cochrane, G. R. (1 January 2009). "Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009". Nucleic Acids Research. 37 (Database): D1–D4. doi:10.1093/nar/gkn942. PMC 2686608. PMID 19033364.
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