GGA2

ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.[5][6][7]

GGA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGGA2, VEAR, golgi associated, gamma adaptin ear containing, ARF binding protein 2
External IDsOMIM: 606005 MGI: 1921355 HomoloGene: 22860 GeneCards: GGA2
Orthologs
SpeciesHumanMouse
Entrez

23062

74105

Ensembl

ENSG00000103365

ENSMUSG00000030872

UniProt

Q9UJY4

Q6P5E6

RefSeq (mRNA)

NM_015044
NM_138640

NM_028758

RefSeq (protein)

NP_055859

NP_083034

Location (UCSC)Chr 16: 23.46 – 23.52 MbChr 7: 121.59 – 121.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.[7]

Interactions

GGA2 has been shown to interact with RABEP1,[8] Sortilin 1,[9][10] BACE2[11] and CLINT1.[12][13]

References

  1. GRCh38: Ensembl release 89: ENSG00000103365 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030872 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
  6. Boman AL, Zhang CJ, Zhu X, Kahn RA (Apr 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
  7. "Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2".
  8. Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  9. Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". The EMBO Journal. 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. PMC 125444. PMID 11331584.
  10. Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM (Jan 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Letters. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067. S2CID 21977507.
  11. He X, Chang WP, Koelsch G, Tang J (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Letters. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764. S2CID 42042430.
  12. Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (Sep 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151. PMID 12213833.
  13. Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846.

Further reading

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