Gamma-glutamyltransferase 6

GGT6
Identifiers
Aliases	GGT6, gamma-glutamyltransferase 6
External IDs	OMIM: 612341 MGI: 1918772 HomoloGene: 51918 GeneCards: GGT6
EC number	3.4.19.13
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	4,560,818 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	72,329,226 bp[2]
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; parotid gland; ; skin of abdomen; ; rectum; ; body of pancreas; ; kidney; ; duodenum; ; minor salivary gland; ; renal medulla; ; vulva;
	Top expressed in
	lip; ; left colon; ; Paneth cell; ; esophagus; ; jejunum; ; left lobe of liver; ; ileum; ; proximal tubule; ; duodenum; ; skin of abdomen;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glutathione hydrolase activity; acyltransferase activity; hydrolase activity; hypoglycin A gamma-glutamyl transpeptidase activity; molecular function; leukotriene C4 gamma-glutamyl transferase activity;
Cellular component	integral component of membrane; extracellular exosome; membrane;
Biological process	glutathione biosynthetic process; proteolysis; glutathione catabolic process; glutathione metabolic process; leukotriene D4 biosynthetic process; biological process;
	Sources:Amigo / QuickGO
Orthologs
	124975
	71522
	ENSG00000167741
	ENSMUSG00000040471
	Q6P531
	Q6PDE7
	NM_153338; NM_001122890; NM_001288702; NM_001288703; NM_001288704
	NM_027819
	NP_001116362; NP_001275631; NP_001275632; NP_001275633; NP_699169
	NP_082095
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-glutamyltransferase 6 is a protein that in humans is encoded by the GGT6 gene. [5]

Function

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).

GRCh38: Ensembl release 89: ENSG00000167741 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040471 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Gamma-glutamyltransferase 6". Retrieved 2016-03-11.