GMEB1

Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene.[5][6][7]

GMEB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGMEB1, P96PIF, PIF96, glucocorticoid modulatory element binding protein 1
External IDsOMIM: 604409 MGI: 2135604 HomoloGene: 10647 GeneCards: GMEB1
Orthologs
SpeciesHumanMouse
Entrez

10691

56809

Ensembl

ENSG00000162419

ENSMUSG00000028901

UniProt

Q9Y692

Q9JL60

RefSeq (mRNA)

NM_006582
NM_024482
NM_001319674

NM_001122992
NM_020273

RefSeq (protein)

NP_001306603
NP_006573
NP_077808

NP_001116464
NP_064669

Location (UCSC)Chr 1: 28.67 – 28.72 MbChr 4: 132.22 – 132.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.[7]

Interactions

GMEB1 has been shown to interact with TRIM63.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000162419 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028901 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Thériault JR, Charette SJ, Lambert H, Landry J (Jul 1999). "Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein". FEBS Lett. 452 (3): 170–176. doi:10.1016/S0014-5793(99)00634-1. PMID 10386584. S2CID 20049223.
  6. Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC 84824. PMID 10523663.
  7. "Entrez Gene: GMEB1 glucocorticoid modulatory element binding protein 1".
  8. McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J Cell Biol. 157 (1): 125–136. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.

Further reading


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