GNL3

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.[4][5][6] It is found within the nucleolus that binds p53.[7] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.[7] It is a marker for many stem cells and cancer cells.[8]

GNL3
Identifiers
AliasesGNL3, C77032, E2IG3, NNP47, NS, G protein nucleolar 3
External IDsOMIM: 608011 MGI: 1353651 HomoloGene: 56670 GeneCards: GNL3
Orthologs
SpeciesHumanMouse
Entrez

26354

30877

Ensembl

n/a

ENSMUSG00000042354

UniProt

Q9BVP2

Q8CI11

RefSeq (mRNA)

NM_206826
NM_014366
NM_206825

NM_153547
NM_178846

RefSeq (protein)

NP_055181
NP_996561
NP_996562

NP_705775

Location (UCSC)n/aChr 14: 30.73 – 30.74 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

GNL3 has been shown to interact with Mdm2[9] and P53.[5]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000042354 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res. 60 (21): 5977–5983. PMID 11085516.
  5. Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev. 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC 187487. PMID 12464630.
  6. "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)".
  7. Ross, Michael H.; Pawlina, Wojciech. (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. p. 79. ISBN 978-0-7817-7200-6.
  8. Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN 978-90-481-9898-6. Retrieved 27 September 2011.
  9. Dai MS, Sun XX, Lu H (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–4376. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907.

Further reading

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