GOSR1

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.[5][6][7][8]

GOSR1
Identifiers
AliasesGOSR1, GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28, golgi SNAP receptor complex member 1
External IDsOMIM: 604026 MGI: 1858260 HomoloGene: 37977 GeneCards: GOSR1
Orthologs
SpeciesHumanMouse
Entrez

9527

53334

Ensembl

ENSG00000108587

ENSMUSG00000010392

UniProt

O95249

O88630

RefSeq (mRNA)

NM_001007024
NM_001007025
NM_004871

NM_016810
NM_001356321

RefSeq (protein)

NP_001007025
NP_001007026
NP_004862

NP_058090
NP_001343250

Location (UCSC)Chr 17: 30.48 – 30.53 MbChr 11: 76.62 – 76.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[8]

Interactions

GOSR1 has been shown to interact with USO1,[9] BET1L[9][10] and STX5.[9][11][12][13]

References

  1. GRCh38: Ensembl release 89: ENSG00000108587 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000010392 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Subramaniam VN, Peter F, Philp R, Wong SH, Hong W (May 1996). "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport". Science. 272 (5265): 1161–3. Bibcode:1996Sci...272.1161S. doi:10.1126/science.272.5265.1161. PMID 8638159. S2CID 42813531.
  6. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  7. Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.
  8. "Entrez Gene: GOSR1 golgi SNAP receptor complex member 1".
  9. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
  10. Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
  11. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
  12. Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
  13. Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF). The Journal of Biological Chemistry. 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. PMID 9325254. S2CID 12818072.

Further reading



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